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Statins use may slow prostate cancer progression

A recent study published in the journal Cancer Epidemiology, Biomarkers & Prevention found men who took statins to lower their cholesterol before prostate cancer surgery had significantly lower inflammation within prostate tumors. Inflammation within tumors has been associated with cancer progression and more aggressive tumor growth, researchers said. "We found that preoperative statin use was associated with a 69 percent lower risk of intra-tumoral inflammation," said Dr. Lionel Baņez, an assistant professor of surgery and urology at Duke and the lead author of the study. "We also discovered a trend suggesting greater risk-reduction with higher doses of the drugs." The Duke researchers examined tissue samples of tumors from 236 men undergoing surgery for prostate cancer at the Durham VA Medical Center. Researchers identified the samples as coming from statin-users or non-users, tracked the dose and frequency among the users, and graded the degree of inflammation in the tissue samples as absent, mild, or marked. They found that 37 patients (16 percent) took statins during the year prior to their prostate surgeries. Most of the statin users (92 percent) were on simvastatin (ZocorŪ). Among all patients, 82 percent had inflammatory cells in their prostate tumors, with roughly one-third registering marked tumor inflammation. After taking into consideration factors such as age, race, body mass index and other clinical variables, investigators found that statin use was associated with reduced inflammation within the tumors. Older patients with more advanced cancers were most likely to have tumor inflammation and have the longest times from biopsy to surgery.
Comments
May 18, 2010 at 2:28 pm
(1) Steve says:

The article reads in part, “statins to lower their cholesterol before prostate cancer surgery,” in reference to statins slow prostate cancer progression. I didn’t even know what statins were until I read this article. My wife works at SportAid.com where they sell medical supplies, and she didn’t even know what they were. I have been taking simvastatin (ZocorŪ) for several years so I guess it is doing or will be doing more for me than “lowering” my cholesterol. Thanks for sharing!

September 11, 2010 at 2:12 am
(2) Urologist says:

It would be good if there was an explanation as to what statins are. And doesn’t any anti-inflammatory solution produce the results of the finding?

June 23, 2011 at 5:46 am
(3) Holmium Laser says:

Reading your article I like most of them is We also discovered a trend suggesting greater risk-reduction with higher doses of the drugs. Thanks for sharing such a nice blogHolmium Laser

June 23, 2011 at 5:47 am
(4) Holmium Laser says:

I like your post Thanks for sharing such a nice blog articleHolmium Laser

November 9, 2011 at 5:09 am
(5) health benefits says:

had much to say “too often can have s*x prostate cancer resulted in” I think it’s wrong.

December 2, 2011 at 7:18 am
(6) Frodo says:

I resolve this problem here

September 12, 2012 at 7:54 am
(7) Handy Orten says:

Impotent men hardly ever experienced it so great. Viagra pioneered the oral cure for Erection Dysfunction. Plus the baton, it seems, has been transferred to Cialis. Between, Levitra also built its presence felt. But Cialis will be the long run drug which has the planet on its toes.

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